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Novel mechanisms targeting endogenous immune ‘brakes’ to restore immune homeostasis.
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Multiple populations of immune cells serve to maintain immune equilibrium. These natural regulatory mechanisms are deficient in many autoimmune diseases.
Mechanisms enhancing immunomodulatory functions of regulatory cells have the potential to provide long-term remission to the patients with immune-mediated diseases.
We are seeking partners with innovative ideas on developing novel therapeutic targets and pathways to induce and sustain the immunomodulatory functions of:
1) CD4+ regulatory T-cells
2) Regulatory B-cells
3) Myeloid-derived suppressor cells
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