GPCR Agonists

Orally bioavailable small molecule agonists of family B GPCR receptors.

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Class B G-protein-coupled receptors (GPCR) of the secretin family are extremely important drug targets across many human diseases. Indeed modulators of this receptor family are amongst the most promising and efficacious therapies for the treatment of metabolic disease, including type 2 diabetes
 
Class B GPCRs are difficult to target with small molecules and the majority of approved medicines and peptide-based agonists require subcutaneous administration
 
We are seeking innovative partners with novel ideas on how to develop orally bioavailable small molecule agonists for Class B GPCRs